March 17, 2026 ### Balancing the Risks and Rewards of Drug Development in China: A Small Biotech CEO Perspective Of the recurring themes that tend to circulate in the drug development discourse,  China is a uniquely fascinating and polarizing... by Jonathan Montagu [Read more](/content/balancing-the-risks-and-rewards-of-drug-development-in-china-a-small-biotech-ceo-perspective/index.html) July 31, 2025 ### A “Complex” Solution to a “Complex” Problem? Attacking KRASG12X Colorectal Cancer Through the CBM Signalosome As scientists, we are accustomed to learning something new about targets (and the modulation thereof) that moves the field forward... by Geraldine Harriman [Read more](/content/a-complex-solution-to-a-complex-problem-attacking-krasg12x-colorectal-cancer-through-the-cbm-signalosome/index.html) February 5, 2025 ### A New Wave of Therapeutic Innovation Through Targeting Transcription Factors In the perpetual and never-ending race by the healthcare sector to unearth new approaches and therapeutics to address disease, one... by Jonathan Montagu [Read more](/content/a-new-wave-of-therapeutic-innovation-through-targeting-transcription-factors/index.html) October 10, 2024 ### ESMO Reflections: Glimmers of Hope with the Next Wave of I-O Therapies? HotSpot’s trip to Barcelona for the recent European Society of Medical Oncology (ESMO) Annual Meeting was no ‘European Vacation,’ but... by Jonathan Montagu [Read more](/content/esmo-reflections-glimmers-of-hope-with-the-next-wave-of-i-o-therapies/index.html) May 9, 2024 ### Has Spring Sprouted New Growth in Immuno-Oncology? As Boston’s weather has started its turn from the frigid darkness that is a northeast winter to the longer days... by Jonathan Montagu [Read more](/content/has-spring-sprouted-new-growth-in-immuno-oncology/index.html) February 7, 2024 ### Drug Discovery: Taking Inspiration from Facial Recognition At HotSpot, we’re harnessing insights from nature by pinpointing specialized protein on/off switches, or pockets, called “natural hotspots.” To date,... by Geraldine Harriman [Read more](/content/drug-discovery-taking-inspiration-from-facial-recognition/index.html) January 3, 2024 ### Signaling Complexes: A Ripe Opportunity for Drug Development Signaling pathways are the intricate networks that govern cell behavior, lying at the crux of cell function. They are used... by Jonathan Montagu [Read more](/content/signaling-complexes-a-ripe-opportunity-for-drug-development/index.html) July 11, 2023 ### On the Road at ASCO 2023: Key Takeaways, Observations and Reflections The American Cancer Society for Oncology (ASCO) annual meeting is among the highlights of the clinical oncology calendar. The meeting... by Amanda Redig [Read more](/content/on-the-road-at-asco-2023-key-takeaways-observations-and-reflections/index.html) June 1, 2023 ### How We Balance the What and How at HotSpot At HotSpot, we are committed to building something we believe is truly distinctive, setting ourselves apart from our peers in... by Jonathan Montagu [Read more](/content/how-we-balance-the-what-and-how-at-hotspot/index.html) March 1, 2023 ### Build It and They Will Come – New Review Spotlights the Scientific Momentum Building for CBL-B Inhibition The phrase ‘build it and they will come’ dates all the way back to the Old Testament, and in more... by Jonathan Montagu [Read more](/content/build-it-and-they-will-come-new-review-spotlights-the-scientific-momentum-building-for-cbl-b-inhibition/index.html)