Scientist, Biochemistry

Full-time, hybrid role based in Boston, MA

At HotSpot, we’re not just looking for the brightest minds or for the most brilliant individual contributors. We want passionate team members who are comfortable adjusting their lens, aren’t afraid to think big, test bold ideas, and celebrate collective wins. We have established core values that resemble who we are and define our company culture. We are building a company where values drive everything we do inside and outside the organization.

Core Values

• #Courageous Adventurers
• #Leave your Mark
• #Keep it Human
• #Make it Real

RESPONSIBILITIES:

• Lead from the bench in the design, development, validation, and implementation of novel biochemical assays targeting allosteric sites for small molecule screens, hits validation, and mechanism of action studies.
• Provide expert knowledge of biochemical mechanisms for small molecule interactions with target proteins and serve on cross-functional project teams as the biochemistry expert.
• Help manage external CROs in assay development, transfer, and validation, to support library screens, hit validation, hit to lead, and lead optimization. Ensure quality control of data entering the corporate database.
• Effectively interact with colleagues in biophysics, structural biology, cell and chemical biology, computational and medicinal chemistry, plus other functional groups such as Immunology and Oncology, to apply biochemical tools to solve project specific problems driving project progression.
• Proficiently use a wide range of biochemical assay methods such as TR-FRET, AlphaLISA, FP, TRIC/Spectral shift, MSD, TSA/Nano-DSF, DLS, etc., to characterize target proteins and interactomes; willingness to develop cell-based target engagement assays is a plus.
• Contribute to the design, expression, and purification of recombinant proteins for biochemical and biophysical assay development and validation.
• Present complex experimental data and insights to cross-functional teams, clearly articulating findings, recommendations, and project impact to support decision-making.
• Stay scientifically current with willingness to implement new technologies to the biochemical assays focusing on allosteric binding sites.
• Make intellectual contributions to all stages of drug discovery process and project deliverables. Clearly articulate goals, progress, and issues to drug discovery teams.

QUALIFICATIONS:

• Ph.D. degree in biochemistry, biophysics, or a related discipline with demonstrated level of expertise and a minimum of 2+ years of relevant experience in small-molecule drug discovery, including industry or a combination of post-doctoral and industry experience; BS/MS degree in biochemistry or a related discipline with 4-8 years of relevant industry experience may be considered.
• Extensive experience in biochemical assay development for protein interactions, including methods such as TR-FRET, AlphaLISA, FP, MST, MSD, TSA/Nano-DSF, etc.; experience and knowledge of cell-based target engagement methods is a plus.
• Some experience developing and implementing biochemical assays to support small-molecule drug discovery and/or MOA elucidation using a variety of detection formats. Experience with allosteric binding sites on proteins is a plus.
• Willing to work with CROs to solve problems and drive progress.
• Strong interpersonal and communication skills, and ability to work seamlessly with multiple drug discovery teams to provide biochemistry support at all stages.
• Excellent organization and management skills, including the ability to set high but reachable goals, ability to manage multiple projects and capability to prioritize.
• Strong interpersonal, influencing and collaboration skills to work in a team-oriented, matrix environment, and the ability to work independently and effectively within tight timelines.
• Outstanding verbal and written communication abilities with a strong publication record.
• Ability and willingness to learn and adopt emerging technologies to drug discovery process.
• Ability to adapt to and effectively manage changes in a fast paced, dynamic environment.
• A passion for drug discovery and sense of urgency to find new medicines for patients.

OUR BENEFITS:

We believe that people are our greatest resource and foster a supportive environment that provides growth and development for all teammates. We recognize and reward performance and incentivizes long-term success. From benefits that focus on your health and well-being to competitive compensation to ownership in the company, we want to inspire our employees.

Our Benefits Include, But Are Not Limited To:

• Competitive salary and bonus plans
• New hire stock option award
• Comprehensive package of benefits plans and fringe benefits
• Generous paid holidays, time off, including 2 company wide shutdowns
• Flexible working arrangements; hybrid work model
• Amazing team of supportive colleagues

At HotSpot, we have a bold mission to establish new drug discovery paradigm. If this appeals to you, please let us know at iamcurious@hotspotthera.com.

HotSpot is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

At this time, HotSpot is not able to offer Visa sponsorship for this position. Candidates must be authorized to work in the United States without current or future sponsorship.

Apply today!

iamcurious@hotspotthera.com