Smart Allostery™ - HotSpot Therapeutics
Elucidating natural hotspot targets
Uncovering natural hotspots is a daunting challenge due to the variety of mechanisms that nature has developed to control the cell. Unlike traditional active sites, natural hotspots are often hidden from sight and require a deep understanding of structure-function to unveil.
The Smart Allostery™ platform takes a systems-wide view to uncover protein pockets with previously unknown regulatory relationships.
Unique Properties of Natural Hotspots
Natural hotspots have intrinsic characteristics that have made them hard for industry to drug, explaining why these pockets remain largely unexploited. Natural hotspots are:
Elusive
Out of the many pockets in a protein, few are decisive in protein function, and many are not visible in crystal structures. Our technology uncovers hidden pockets and identifies the sites that drive protein function.
Transient
Natural hotspots are not present in certain protein conformations, reducing the likelihood that chemical screening campaigns will succeed. A specialized pharmacology and in silico toolkit is required to identify compounds that bind these pockets.
Undrugged
Existing chemical libraries built around active sites are poorly aligned with the pharmacological footprint of natural hotspots. To successfully drug natural hotspots, new chemical scaffolds are required, powered by advanced computational science.
Our process
We believe our Smart Allostery™ platform is the first technology platform designed to systematically identify natural hotspots and enable the design of potent, selective, allosteric modulators. We integrate insights from biology, computational sciences, chemistry and biophysics to systematically identify and drug natural hotspots.
SpotBinder
SpotCapture
SpotFinder™
Smart Allostery™ integrates three discrete component technologies:
SpotFinder™
Uncover natural hotspot pockets using AI powered engine
SpotCapture
Target hotspots with small molecules using suite of specialized in vitro & in silico assays
SpotBinder
Deliver medicines using library containing approximately 800 million custom molecules
Our Pipeline
Smart Allostery™ is being leveraged across entire target classes to enable pipeline development.