Home - HotSpot Therapeutics
New paradigm for allosteric drug discovery
Humans have long aspired to imitate things we see in nature – birds inspired airplanes, the brain produced AI, and stars taught us how to create clean energy.
Within every cell, nature has engineered molecular mechanisms to combat disease. And yet, these mechanisms have never served as the inspiration for medicines… Until now.
At HotSpot, we are leading the way in targeting cellular on/off switches that are critical to a protein’s endogenous function - natural hotspots.
Smart Allostery™
Our platform - Smart Allostery™ - integrates structure-function, cutting-edge pharmacology, tailored chemistry, and deep AI capabilities to systematically uncover and drug natural hotspots.
Through our proprietary platform, we are pioneering the discovery of novel allosteric medicines.
Unlocking disease biology
Using our Smart Allostery™ platform, we are pioneering the discovery of novel allosteric medicines to treat autoimmune diseases.
Press releases
June 4, 2026
HotSpot Therapeutics Presents Preclinical Data from Small Molecule IRF5 Inhibitor Program at EULAR 2026
May 20, 2026